Press releases

Mit neuer Technik viel schneller zum Impfstoff

Badische Zeitung; published 2020/02/18


Kopieren ausdrücklich erwünscht!

Laborjournal, April 2017


Impfrevolution durch Kopierverfahren

BIOPRO Magazin (published 2016/10/17 in


1,6 Millionen für Biomolekül-Kopierer

Bionity (published 2016/08/16 in


Günter Roth hat einen Kopierer gebaut

WIRED Magazin (December 2015)

Gründen in Baden-Württemberg: Günter Roth und der Biomolekül-Kopierer

BIOPRO Baden-Württemberg (published 2015/08/31 in


Forschergruppe des Zentrums für Biosystemanalyse gewinnt Preis für Molekül-Kopierer

Badische Zeitung (published 2015/06/25 in


immune2day gewinnt mit einem Kopiergerät für Biomoleküle das Finale des Start-up Wettbewerbs „Elevator Pitch BW 2014/2015“

GRÜNDERLAND BW (published 2015/06/16 in

The BioCopy concept “immune2day” (our method for the fast identification of vaccine precursors) was awarded 1st place by the Ministry of Finance and Economics of Baden Württemberg.


Wettbewerb Elevator Pitch BW in Lahr

Gründung-BW (published 2015/03/26 in

The BioCopy concept “Apta-SWIFT” (new screening method for the detection and determination of aptamers) was awarded the 2t place.


Gründerpreis der Uni wurde vergeben

Badische Zeitung (published 2014/12/09)

The BioCopy concept “immune2day” was awarded by the University of Freiburg.


Microarray Copying - Biosynthese als Kopierprozess

BIOPRO Baden-Württemberg GmbH (published 2014/02/20)


Mikro-Kopierer für Genomanalysen entwickelt

Gesundheitsindustrie BW (published 2012/08/01)


Erkennung von Umweltschadstoffen durch Aptamere

Stoltenburg, R., Reinemann, C., Strehlitz

Laborwelt, Vol.2, 6-9

DNA aptamer selection using a ligand evolution process

Stoltenburg, R., Reinemann, C., Strehlitz, B.

Am. Biotechnol. Lab., Vol. 24, 18-20

Scientific publications

KOFFI and Anabel 2.0—a new binding kinetics database and its integration in an open-source binding analysis software

Leo William Norval, Stefan Daniel Krämer, Mingjie Gao, Tobias Herz, Jianyu Li, Christin Rath, Johannes Wöhrle, Stefan Günther, Günter Roth

Anal Biochem,

How to copy and paste DNA microarrays

Stefan D. Krämer, Johannes Wöhrle, Philipp A. Meyer, Gerald A. Urban & Günter Roth

Scientific reports9(1), 1-10,

Comparison of different label-free imaging high-throughput biosensing systems for aptamer binding measurements using thrombin aptamers

Christin Rath, Jürgen Burger, Leo Norval, Stefan Daniel Krämer, Nicole Gensch, Alexander van der Kooi, Christine Reinemann, Ciara O’Sullivan, Marketa Svobodova, Günter Roth

Anal Biochem,

Protein Microarray Copying: Easy on-Demand Protein Microarray Generation Compatible with Fluorescence and Label-Free Real-Time Analysis

Normann Kilb, Tobias Herz, Jürgen Burger, Johannes Wöhrle, Philipp A. Meyer, Günter Roth


Anabel: An Online Tool for the Real-Time Kinetic Analysis of Binding Events

Stefan D Krämer, Johannes Wöhrle, Christin Rath, Günter Roth

Bioinformatics and Biology Insights,

A joint action of aptamers and gold nanoparticles chemically trapped on a glassy carbon support for the electrochemical sensing of ofloxacin

Sanaz Pilehvar, Christine Reinemann, Fabio Bottari, Els Vanderleyden, Sandra Van Vlierberghe, Ronny Blust, Beate Strehlitz, Karolien De Wael

Sensors Actuators B,

Professionell begleitete Hightech-Ausgründungen als Königsweg.

Dr. Wolfgang Jost, Niko Bausch, Prof. Dr. Bernhard Arnolds

Best Practice Technologietransfer Baden-Württemberg, Beispiele erfolgreicher Transfersysteme, BIOPRO Baden-Württemberg, 26-33

Generation and characterization of quinolone-specific DNA aptamers suitable for water monitoring

Christine Reinemann, Ulrike Freiin von Fritsch, Sophie Rudolph, Beate Strehlitz

Biosens Bioelectron,

Low-Volume Label-Free Detection of Molecule-Protein Interactions on Microarrays by Imaging Reflectometric Interferometry

Juergen Burger, Christin Rath, Johannes Woehrle, Philipp A. Meyer, Nessim Ben Ammar, Normann Kilb, Thomas Brandstetter, Florian Pröll, Guenther Proll, Gerald Urban, Guenter Roth

Journal of Laboratory Automation, DOI: 10.1177/2211068216657512

Semi-contact-writing of polymer molds for prototyping PDMS chips with low surface roughness, sharp edges and locally varying channel heights

Ludwig Gutzweiler, Fabian Stumpf, Laurent Tanguy, Guenter Roth, Peter Koltay, Roland Zengerle, Lutz Riegger

2016 J Micromech Microeng, Band: 26, Nummer: 4, Seiten: 45018 – 45027: DOI: 10.1088/0960-1317/26/4/045018

Single-cell PCR of genomic DNA enabled by automated single-cell printing for cell isolation

Stumpf, J. Schoendube, A. Gross, C. Rath, S.Niekrawietz, P. Koltay, G. Roth

Biosens Bioelectron; DOI 10.1016/j.bios.2015.03.008

Identification of the target binding site of ethanolamine binding aptamers and its exploitation for ethanolamine detection

Alexandra Heilkenbrinker, Christine Reinemann, Regina Stoltenburg, Johanna-Gebriela Walter, André Jochums, Frank Stahl, Stefan Zimmermann, Beate Strehlitz, Thomas Scheper

Anal Chem,

S-layer proteins as an immobilization matrix for aptamers on different sensor surfaces

Ulrike Weinert, Manja Vogel, Christine Reinemann, Beate Strehlitz, Katrin Pollmann, Johannes Raff

Eng Life Sciences,

A Peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction.

Joris Witsenburg, Michael D. Sinzinger, Dr. Oda Stoevesandt, Dr. Ivo R. Ruttekolk, Dr. Günter Roth, Dr. Merel J. W. Adjobo‐Hermans, Prof. Dr. Roland Brock

Chembiochem; DOI 10.1002/cbic.201402622

Protein microarray generation by in situ protein expression from template DNA

Normann Kilb, Jürgen Burger, Günter Roth

Engineering in Life Sciences; DOI 10.1002/elsc.201300052

Aptamer-modified nanoparticles and their use in cancer diagnostics and treatment

Christine Reinemann, Beate Strehlitz

Swiss Med Wkly,

Real-time PCR based detection of a panel of food-borne pathogens on a centrifugal microfluidic ``LabDisk`` with on-disk quality controls and standards for quantification

Oliver Strohmeier, Nico Marquart, Daniel Mark, Günter Roth, Roland Zengerle and Felix von Stetten

Analytical Methods; DOI 10.1039/C3AY41822G

Human Papillomavirus DNA and Host Gene mRNA Biomarker Detection in a ``Micro Total Analysis System`` (microTAS) Device to Aid Diagnosis of Cervical Intraepithelial Neoplasia

Keegan H. and Roth, G. et. al.

Modern Pathology;

A Quantitative Assessment of Costimulation and Phosphatase Activity on Microclusters in Early T Cell Signaling

Joris Witsenburg, Heike Glauner, Jörg P. Müller, Johannes M. M. Groenewoud, Günter Roth, Frank-Dietmar Böhmer, Merel J. W. Adjobo-Hermans, Roland Brock

PLOS ONE; DOI 10.1371/journal.pone.0079277

Centrifugal gas-phase transition magnetophoresis (GTM)‐a generic method for automation of magnetic bead based assays on the centrifugal microfluidic platform and application to DNA purification

Oliver Strohmeier, Alexander Emperle, Günter Roth, Daniel Mark, Roland Zengerle  and  Felix von Stetten

Lab on a Chip; DOI 10.1039/c2lc40866j

Aptamer-nanomaterial conjugates for medical applications

Christine Reinemann, Beate Strehlitz

In: Bioengineered Nanomaterials, Ed.: Tiwari, A. & Tiwari, A.,  Taylor & Francis publication (CRC Press) USA, 2013, ISBN: 978-1-4665-8595-9,

Multiplex genotyping of KRAS point mutations in tumor cell DNA by allele-specific real-time PCR on a centrifugal microfluidic disk segment

Oliver Strohmeier, Silke Laßmann, Bianca Riedel, Daniel Mark, Günter Roth, Martin Werner, Roland Zengerle, Felix von Stetten

Microchimica Acta; DOI 10.1007/s00604-013-1099-z

Bubble Jet agent release cartridge for chemical single cell stimulation

Wangler, M. Welsche, M. Blazek, M. Blessing, M. Vervliet-Scheebaum, R. Reski, C. Müller, H. Reinecke, J. Steigert, G. Roth, R. Zengerle, N. Paust

Biomedical microdevices; DOI 10.1007/s10544-012-9681-4

Aptamers for pharmaceuticals and their application in environmental analytics

Beate Strehlitz, Christine Reinemann, Sören Linkorn, Regina Stoltenburg

Bioanal Rev,

Mediator probe PCR: a novel approach for detection of real-time PCR based on label-free primary probes and standardized secondary universal fluorogenic reporters

Faltin, B.; Wadle, S.; Roth, G.; Zengerle, R.; Stetten, F. v.

Clinical chemistry; DOI 10.1373/clinchem.2012

Universal protocol for grafting PCR primers onto various lab-on-a-chip substrates for solid-phase PCR

Jochen Hoffmann, Sebastian Hin, Felix von Stetten, Roland Zengerle and  Günter Roth

RSC Advances; DOI 10.1039/C2RA01250B

Solid-phase PCR in a picowell array for immobilizing and arraying 100000 PCR products to a microscope slide

Jochen Hoffmann, Martin Trotter, Felix von Stetten, Roland Zengerle  and  Günter Roth

Lab on a Chip; DOI 10.1039/c2lc40534b

Construction of a Microstructured Collagen Membrane Mimicking the Papillary Dermis Architecture and Guiding Keratinocyte Morphology and Gene Expression

Gerwen Lammers, Günter Roth, Mathias Heck, Roland Zengerle, G. Sandra Tjabringa, Elly M. Versteeg et al.

Macromolecular bioscience; DOI 10.1002/mabi.201100443

Centrifugo-dynamic inward pumping of liquids on a centrifugal microfluidic platform

Steffen Zehnle, Frank Schwemmer, Günter Roth, Felix von Stetten, Roland Zengerle and Nils Paust

Lab on a Chip; DOI 10.1039/c2lc40942a

Nanotechnology-based biosensors and diagnostics: technology push versus industrial/healthcare requirements

Sandeep Kumar Vashist, A. G. Venkatesh, Konstantinos Mitsakakis, Gregor Czilwik, Günter Roth, Felix von Stetten, Roland Zengerle

BioNanoScience; DOI 10.1007/s12668-012-0047-4

Controlled counter-flow motion of magnetic bead chains rolling along microchannels

Marc Karle, Johannes Wöhrle, Junichi Miwa, Nils Paust, Günter Roth, Roland Zengerle, Felix von Stetten

Microfluidics and Nanofluidics; DOI 10.1007/s10404-010-0727-8

Protein expression from exogenous mRNA: uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

Christina Lorenz, Mariola Fotin-Mleczek, Günter Roth, Christina Becker, Thanh Chau Dam, Wouter P. R. Verdurmen et al.

RNA biology; DOI 10.4161/rna.8.4.15394

Antineuronal antibodies in sporadic late-onset cerebellar ataxia

Bürk, M. Wick, G. Roth, P. Decker, R. Voltz

Journal of neurology; DOI 10.1007/s00415-009-5262-8

Microstructuring of polymer films for sensitive genotyping by real-time PCR on a centrifugal microfluidic platform

Maximilian Focke, Fabian Stumpf, Bernd Faltin, Patrick Reith, Dylan Bamarni, Simon Wadle, Claas Müller, Holger Reinecke, Jacques Schrenzel, Patrice Francois, Daniel Mark,  Günter Roth, Roland Zengerle and  Felix von Stetten

Lab on a Chip; DOI 10.1039/c004954a

Centrifugal microfluidic system for primary amplification and secondary real-time PCR

Maximilian Focke, Fabian Stumpf, Günter Roth, Roland Zengerle and Felix von Stetten

Lab on a Chip ; DOI 10.1039/c0lc00161a

Peptide microarrays for the profiling of cytotoxic T-lymphocyte activity using minimum numbers of cells

Antje Hoff, Ana-Cristina Bagû, Thomas André, Günter Roth, Karl-Heinz Wiesmüller, Brigitte Gückel, Roland Brock

Cancer Immunology, Immunotherapy ; DOI 10.1007/s00262-010-0867-4

Continuous microfluidic DNA extraction using phase-transfer magnetophoresis

Marc Karle, Junichi Miwa, Gregor Czilwik, Volker Auwärter, Günter Roth, Roland Zengerle  and  Felix von Stetten

Lab on a Chip ; DOI 10.1039/c0lc00129e

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

Jost Leemhuis, Elisabeth Bouché, Michael Frotscher, Frank Henle, Lutz Hein, Joachim Herz, Dieter K. Meyer, Marina Pichler, Günter Roth, Carsten Schwan and Hans H. Bock

The Journal of Neuroscience; DOI 10.1523/JNEUROSCI.4036-10.2010

Microfluidic lab-on-a-foil for nucleic acid analysis based on isothermal recombinase polymerase amplification (RPA)

Sascha Lutz, Patrick Weber, Max Focke, Bernd Faltin, Jochen Hoffmann, Claas Müller, Daniel Mark, Günter Roth et al.

Lab on a Chip; DOI 10.1039/b921140c

Lab-on-a-chip solutions designed for being operated on standard laboratory instruments

D.Mark, M.Focke, S.Lutz, J.Burger, M.Müller, L.Riegger, M.Rombach, J.Hoffmann, G.Roth, O.Piepenburg, Y.Park, R.Zengerle, F.von Stetten

Procedia Engineering; DOI 10.1016/j.proeng.2010.09.142

Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications

Daniel Mark, Stefan Haeberle, Günter Roth, Felix von Stetten  and  Roland Zengerle

Chemical Society Reviews ; DOI 10.1039/B820557B

Neurological symptoms in patients with biopsy proven celiac disease

Katrin Bürk MD, Marie-Louise Farecki, Georg Lamprecht MD, Guenter Roth PhD, Patrice Decker PhD, Michael Weller MD, Hans-Georg Rammensee PhD, Wolfang Oertel MD

Movement Disorders; DOI 10.1002/mds.22821

Aptamere für Biosensoren

Christine Reinemann

Südwestdeutscher Verlag, 2009, ISBN: 978-3838100418

Investigations on the Specificity of DNA Aptamers Binding to Ethanolamine

Christine Reinemann, Regina Stoltenburg, Beate Strehlitz

Anal Chem,

Physiologische Assays in einem DVD Player am Beispiel der Messung des Hämatokrit

J. Burger, D. Mark, G. Roth, C. Müller, R. Zengerle, F. von Stetten, Y. Park


Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration

Fiona J. Culley, Matthew Johnson, J. Henry Evans, Sunil Kumar, Rupert Crilly, Juan Casasbuenas, Günter Roth et al.

PLoS Biol; DOI 10.1371/journal.pbio.1000159

Diffusion-Driven Device for a High-Resolution Dose- Response Profiling of Combination Chemotherapy

Alexander Ganser, Günter Rothet al.

Analytical Chemistry; DOI 10.1021/ac900415s

Mikrofluidik-Plattform zur kontinuierlichen Aufreinigung von Biomolekülen

M. Karle, J. Miwa Dr. , S. Haeberle Dr. , G. Roth Dr. , R. Zengerle Prof. Dr. , F. von Stetten Dr.

Chemie Ingenieur Technik;

Kontinuierlich arbeitende Mikrofluidik-Plattform zur Aufreinigung von Biomolekülen

Karle, Marc; Haeberle, Stefan; Miwa, Junichi; Roth, Günter; Zengerle, Roland; Stetten, Felix von Stetten


Isothermal Polymerase Amplification in a Centrifugal Microfluidic Foil Cartridge

S.Lutz, P.Weber, M.Focke, B.Faltin, G.Roth, O.Piepenburg, N.Armes, D.Mark, R.Zengerle, F.von Stetten

Procedia Chemistry; DOI 10.1016/j.proche.2009.07.132

Lab-on-a-Chip Foundry Service: Schnelle kundenspezifische Implementierung miniaturisierter biochemischer Assays

Metz, T.; Karle, M.; Preis, T.; Mark, D.; Roth, G.; Müller, C. et al.


Stimulus Dependence of the Action of Small-Molecule Inhibitors in the CD3/CD28 Signalling Network

Karsten Köhler Dr., Alexander Ganser, Thomas André Dr., Günter Roth Dr., Ludger Grosse-Hovest Dr., Gundram Jung Prof. Dr., Roland Brock Prof. Dr

ChemMedChem; DOI 10.1002/cmdc.200800134

Ubiquitin Binds to a Short Peptide Segment of Hydrolase UCH-L3: A Study by FCS, RIfS, ITC and NMR

Günter Roth Dr., Stefan Freund Dr., Bernd Möhrle Dr., Karin Wöllner, Jente Brünjes Dr. Günter Gauglitz Prof. Dr. et al.


SELEX – A (r)evolutionary method to generate high-affinity nucleic acid ligands

Regina Stoltenburg, Christine Reinemann, Beate Strehlitz

Biomol Eng,

Development of aptamers as new receptors for environmental biosensors

Regina Stoltenburg, Christine Reinemann, Beate Strehlitz

In: Environmental Biotechnology, Ed.:  Mishra C.S.K., Juwarkar A.A., APH Publishing Corporation, 2007, ISBN: 81-313-01850

Diffusion along microfluidic channels

A.Heeren, C.P.Luo, G.Roth, A.Ganser, R.Brock, K.-H.Wiesmueller et al.

Microelectronic Engineering; DOI 10.1016/j.mee.2006.01.187

Measuring biomolecular binding events with a compact disc player device

Sebastian A. Lange Dr., Günter Roth, Silke Wittemann Dr., Thilo Lacoste Dr., Andreas Vetter, Jürgen Grässle et al.

Angewandte Chemie; DOI 10.1002/ange.200501243

Microsystems for the analysis of cellular signal transduction

Alexander Ganser, Günter Roth, Karsten Köhler, Thomas André, Andreas Heeren, Wolfgang Henschel et al.

NanoBiotechnology; DOI 10.1007/s12030-005-0039-3

In vitro selection of DNA aptamers binding ethanolamine

Doerthe Mann, Christine Reinemann, Regina Stoltenburg, Beate Strehlitz

Biochem Biophys Res Chem,

FluMag-SELEX as an advantageous method for DNA aptamer selection

Regina Stoltenburg, Christine Reinemann, Beate Strehlitz

Anal Bioanal Chem,