Publications
Press Releases
Günter Roth hat einen Kopierer gebaut
WIRED Magazin (published december 2015)
Gründen in Baden-Württemberg: Günter Roth und der Biomolekül-Kopierer
BIOPRO Baden-Württemberg (published 2015/08/31 in www.gesundheitsindustrie-bw.de)
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Forschergruppe des Zentrums für Biosystemanalyse gewinnt Preis für Molekül-Kopierer
Badische Zeitung (published 2015/06/25 at badische-zeitung.de)
Link
immune2day gewinnt mit einem Kopiergerät für Biomoleküle das Finale des Start-up Wettbewerbs „Elevator Pitch BW 2014/2015“
GRÜNDERLAND BW (published 2015/06/16 in wm.baden-wuerttemberg.de)
The BioCopy concept “immune2day” (our method for the discovery of vaccine precursors) was awarded with the 1st place by the Ministry of Finance and Economics of Baden-Württemberg.
Link
Wettbewerb Elevator Pitch BW in Lahr
Gründung-BW (published 2015/03/26 in www.gruendung-bw.de)
The BioCopy concept “Apta-SWIFT” (new screening method for the detection and determination of aptamers) was awarded 2nd place.
Link
Gründerpreis der Uni wurde vergeben
Badische Zeitung (published 2014/12/09 in www.badische-zeitung.de)
The BioCopy concept “immune2day” (our method for the discovery of vaccine precursors) was awarded by the University of Freiburg.
Link
Microarray Copying - Biosynthese als Kopierprozess
BIOPRO Baden-Württemberg GmbH (published 2014/01/20)
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Mikro-Kopierer für Genomanalysen entwickelt
Gesundheitsindustrie BW (published 2012/08/01 in www.gesundheitsindustrie-bw.de)
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Erkennung von Umweltschadstoffen durch Aptamere
Stoltenburg, R., Reinemann, C., Strehlitz
Laborwelt, Vol.2, 6-9
DNA aptamer selection using a ligand evolution process
Stoltenburg, R., Reinemann, C., Strehlitz, B.
Am. Biotechnol. Lab., Vol. 24, 18-20
Scientific Publications
KOFFI and Anabel 2.0—a new binding kinetics database and its integration in an open-source binding analysis software
Leo William Norval, Stefan Daniel Krämer, Mingjie Gao, Tobias Herz, Jianyu Li, Christin Rath, Johannes Wöhrle, Stefan Günther, Günter Roth
Anal Biochem, https://doi.org/10.1016/j.ab.2019.05.012
How to copy and paste DNA microarrays
Stefan D. Krämer, Johannes Wöhrle, Philipp A. Meyer, Gerald A. Urban & Günter Roth
Scientific reports, 9(1), 1-10, https://doi.org/10.1038/s41598-019-50371-1
Comparison of different label-free imaging high-throughput biosensing systems for aptamer binding measurements using thrombin aptamers
Christin Rath, Jürgen Burger, Leo Norval, Stefan Daniel Krämer, Nicole Gensch, Alexander van der Kooi, Christine Reinemann, Ciara O’Sullivan, Marketa Svobodova, Günter Roth
Anal Biochem, https://doi.org/10.1016/j.ab.2019.05.012
Protein Microarray Copying: Easy on-Demand Protein Microarray Generation Compatible with Fluorescence and Label-Free Real-Time Analysis
Normann Kilb, Tobias Herz, Jürgen Burger, Johannes Wöhrle, Philipp A. Meyer, Günter Roth
ChemBioChem, https://doi.org/10.1002/cbic.201800699
Anabel: An Online Tool for the Real-Time Kinetic Analysis of Binding Events
Stefan D Krämer, Johannes Wöhrle, Christin Rath, Günter Roth
Bioinformatics and Biology Insights, https://doi.org/10.1177/1177932218821383
A joint action of aptamers and gold nanoparticles chemically trapped on a glassy carbon support for the electrochemical sensing of ofloxacin
Sanaz Pilehvar, Christine Reinemann, Fabio Bottari, Els Vanderleyden, Sandra Van Vlierberghe, Ronny Blust, Beate Strehlitz, Karolien De Wael
Sensors Actuators B, https://doi.org/10.1016/j.snb.2016.09.075
Professionell begleitete Hightech-Ausgründungen als Königsweg.
Best Practice Technologietransfer Baden-Württemberg, Beispiele erfolgreicher Transfersysteme, BIOPRO Baden-Württemberg, 26-33
Generation and characterization of quinolone-specific DNA aptamers suitable for water monitoring
Christine Reinemann, Ulrike Freiin von Fritsch, Sophie Rudolph, Beate Strehlitz
Biosens Bioelectron, https://doi.org/10.1016/j.bios.2015.10.069
Low-Volume Label-Free Detection of Molecule-Protein Interactions on Microarrays by Imaging Reflectometric Interferometry
Juergen Burger, Christin Rath, Johannes Woehrle, Philipp A. Meyer, Nessim Ben Ammar, Normann Kilb, Thomas Brandstetter, Florian Pröll, Guenther Proll, Gerald Urban, Guenter Roth
Journal of Laboratory Automation, DOI: 10.1177/2211068216657512
Semi-contact-writing of polymer molds for prototyping PDMS chips with low surface roughness, sharp edges and locally varying channel heights
Ludwig Gutzweiler, Fabian Stumpf, Laurent Tanguy, Guenter Roth, Peter Koltay, Roland Zengerle, Lutz Riegger
2016 J Micromech Microeng, Band: 26, Nummer: 4, Seiten: 45018 – 45027: DOI: 10.1088/0960-1317/26/4/045018
Single-cell PCR of genomic DNA enabled by automated single-cell printing for cell isolation
Stumpf, J. Schoendube, A. Gross, C. Rath, S.Niekrawietz, P. Koltay, G. Roth
Biosens Bioelectron; DOI 10.1016/j.bios.2015.03.008
Identification of the target binding site of ethanolamine binding aptamers and its exploitation for ethanolamine detection
Alexandra Heilkenbrinker, Christine Reinemann, Regina Stoltenburg, Johanna-Gebriela Walter, André Jochums, Frank Stahl, Stefan Zimmermann, Beate Strehlitz, Thomas Scheper
Anal Chem, https://doi.org/10.1021/ac503481
S-layer proteins as an immobilization matrix for aptamers on different sensor surfaces
Ulrike Weinert, Manja Vogel, Christine Reinemann, Beate Strehlitz, Katrin Pollmann, Johannes Raff
Eng Life Sciences, https://doi.org/10.1002/elsc.201400204
A Peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction.
Joris Witsenburg, Michael D. Sinzinger, Dr. Oda Stoevesandt, Dr. Ivo R. Ruttekolk, Dr. Günter Roth, Dr. Merel J. W. Adjobo‐Hermans, Prof. Dr. Roland Brock
Chembiochem; DOI 10.1002/cbic.201402622
Protein microarray generation by in situ protein expression from template DNA
Normann Kilb, Jürgen Burger, Günter Roth
Engineering in Life Sciences; DOI 10.1002/elsc.201300052
Aptamer-modified nanoparticles and their use in cancer diagnostics and treatment
Christine Reinemann, Beate Strehlitz
Swiss Med Wkly, https://doi.org/10.4414/smw.2014.13908
Real-time PCR based detection of a panel of food-borne pathogens on a centrifugal microfluidic ``LabDisk`` with on-disk quality controls and standards for quantification
Oliver Strohmeier, Nico Marquart, Daniel Mark, Günter Roth, Roland Zengerle and Felix von Stetten
Analytical Methods; DOI 10.1039/C3AY41822G
Human Papillomavirus DNA and Host Gene mRNA Biomarker Detection in a ``Micro Total Analysis System`` (microTAS) Device to Aid Diagnosis of Cervical Intraepithelial Neoplasia
Keegan H. and Roth, G. et. al.
Modern Pathology; https://doi.org/10.1038/modpathol.2014.29
A Quantitative Assessment of Costimulation and Phosphatase Activity on Microclusters in Early T Cell Signaling
Joris Witsenburg, Heike Glauner, Jörg P. Müller, Johannes M. M. Groenewoud, Günter Roth, Frank-Dietmar Böhmer, Merel J. W. Adjobo-Hermans, Roland Brock
Centrifugal gas-phase transition magnetophoresis (GTM)‐a generic method for automation of magnetic bead based assays on the centrifugal microfluidic platform and application to DNA purification
Oliver Strohmeier, Alexander Emperle, Günter Roth, Daniel Mark, Roland Zengerle and Felix von Stetten
Lab on a Chip; DOI 10.1039/c2lc40866j
Aptamer-nanomaterial conjugates for medical applications
Christine Reinemann, Beate Strehlitz
In: Bioengineered Nanomaterials, Ed.: Tiwari, A. & Tiwari, A., Taylor & Francis publication (CRC Press) USA, 2013, ISBN: 978-1-4665-8595-9, https://doi.org/10.1201/b15403
Multiplex genotyping of KRAS point mutations in tumor cell DNA by allele-specific real-time PCR on a centrifugal microfluidic disk segment
Oliver Strohmeier, Silke Laßmann, Bianca Riedel, Daniel Mark, Günter Roth, Martin Werner, Roland Zengerle, Felix von Stetten
Microchimica Acta; DOI 10.1007/s00604-013-1099-z
Bubble Jet agent release cartridge for chemical single cell stimulation
Wangler, M. Welsche, M. Blazek, M. Blessing, M. Vervliet-Scheebaum, R. Reski, C. Müller, H. Reinecke, J. Steigert, G. Roth, R. Zengerle, N. Paust
Aptamers for pharmaceuticals and their application in environmental analytics
Beate Strehlitz, Christine Reinemann, Sören Linkorn, Regina Stoltenburg
Bioanal Rev, https://doi.org/10.1007/s12566-011-0026-1
Mediator probe PCR: a novel approach for detection of real-time PCR based on label-free primary probes and standardized secondary universal fluorogenic reporters
Clinical chemistry; DOI 10.1373/clinchem.2012
Universal protocol for grafting PCR primers onto various lab-on-a-chip substrates for solid-phase PCR
Jochen Hoffmann, Sebastian Hin, Felix von Stetten, Roland Zengerle and Günter Roth
Solid-phase PCR in a picowell array for immobilizing and arraying 100000 PCR products to a microscope slide
Jochen Hoffmann, Martin Trotter, Felix von Stetten, Roland Zengerle and Günter Roth
Lab on a Chip; DOI 10.1039/c2lc40534b
Construction of a Microstructured Collagen Membrane Mimicking the Papillary Dermis Architecture and Guiding Keratinocyte Morphology and Gene Expression
Gerwen Lammers, Günter Roth, Mathias Heck, Roland Zengerle, G. Sandra Tjabringa, Elly M. Versteeg et al.
Macromolecular bioscience; DOI 10.1002/mabi.201100443
Centrifugo-dynamic inward pumping of liquids on a centrifugal microfluidic platform
Steffen Zehnle, Frank Schwemmer, Günter Roth, Felix von Stetten, Roland Zengerle and Nils Paust
Lab on a Chip; DOI 10.1039/c2lc40942a
Nanotechnology-based biosensors and diagnostics: technology push versus industrial/healthcare requirements
Sandeep Kumar Vashist, A. G. Venkatesh, Konstantinos Mitsakakis, Gregor Czilwik, Günter Roth, Felix von Stetten, Roland Zengerle
BioNanoScience; DOI 10.1007/s12668-012-0047-4
Controlled counter-flow motion of magnetic bead chains rolling along microchannels
Marc Karle, Johannes Wöhrle, Junichi Miwa, Nils Paust, Günter Roth, Roland Zengerle, Felix von Stetten
Microfluidics and Nanofluidics; DOI 10.1007/s10404-010-0727-8
Protein expression from exogenous mRNA: uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway
Christina Lorenz, Mariola Fotin-Mleczek, Günter Roth, Christina Becker, Thanh Chau Dam, Wouter P. R. Verdurmen et al.
RNA biology; DOI 10.4161/rna.8.4.15394
Antineuronal antibodies in sporadic late-onset cerebellar ataxia
Bürk, M. Wick, G. Roth, P. Decker, R. Voltz
Journal of neurology; DOI 10.1007/s00415-009-5262-8
Microstructuring of polymer films for sensitive genotyping by real-time PCR on a centrifugal microfluidic platform
Maximilian Focke, Fabian Stumpf, Bernd Faltin, Patrick Reith, Dylan Bamarni, Simon Wadle, Claas Müller, Holger Reinecke, Jacques Schrenzel, Patrice Francois, Daniel Mark, Günter Roth, Roland Zengerle and Felix von Stetten
Lab on a Chip; DOI 10.1039/c004954a
Centrifugal microfluidic system for primary amplification and secondary real-time PCR
Maximilian Focke, Fabian Stumpf, Günter Roth, Roland Zengerle and Felix von Stetten
Lab on a Chip ; DOI 10.1039/c0lc00161a
Peptide microarrays for the profiling of cytotoxic T-lymphocyte activity using minimum numbers of cells
Antje Hoff, Ana-Cristina Bagû, Thomas André, Günter Roth, Karl-Heinz Wiesmüller, Brigitte Gückel, Roland Brock
Cancer Immunology, Immunotherapy ; DOI 10.1007/s00262-010-0867-4
Continuous microfluidic DNA extraction using phase-transfer magnetophoresis
Marc Karle, Junichi Miwa, Gregor Czilwik, Volker Auwärter, Günter Roth, Roland Zengerle and Felix von Stetten
Lab on a Chip ; DOI 10.1039/c0lc00129e
Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation
Jost Leemhuis, Elisabeth Bouché, Michael Frotscher, Frank Henle, Lutz Hein, Joachim Herz, Dieter K. Meyer, Marina Pichler, Günter Roth, Carsten Schwan and Hans H. Bock
The Journal of Neuroscience; DOI 10.1523/JNEUROSCI.4036-10.2010
Microfluidic lab-on-a-foil for nucleic acid analysis based on isothermal recombinase polymerase amplification (RPA)
Sascha Lutz, Patrick Weber, Max Focke, Bernd Faltin, Jochen Hoffmann, Claas Müller, Daniel Mark, Günter Roth et al.
Lab on a Chip; DOI 10.1039/b921140c
Lab-on-a-chip solutions designed for being operated on standard laboratory instruments
D.Mark, M.Focke, S.Lutz, J.Burger, M.Müller, L.Riegger, M.Rombach, J.Hoffmann, G.Roth, O.Piepenburg, Y.Park, R.Zengerle, F.von Stetten
Procedia Engineering; DOI 10.1016/j.proeng.2010.09.142
Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications
Daniel Mark, Stefan Haeberle, Günter Roth, Felix von Stetten and Roland Zengerle
Chemical Society Reviews ; DOI 10.1039/B820557B
Neurological symptoms in patients with biopsy proven celiac disease
Katrin Bürk MD, Marie-Louise Farecki, Georg Lamprecht MD, Guenter Roth PhD, Patrice Decker PhD, Michael Weller MD, Hans-Georg Rammensee PhD, Wolfang Oertel MD
Movement Disorders; DOI 10.1002/mds.22821
Aptamere für Biosensoren
Christine Reinemann
Südwestdeutscher Verlag, 2009, ISBN: 978-3838100418
Investigations on the Specificity of DNA Aptamers Binding to Ethanolamine
Christine Reinemann, Regina Stoltenburg, Beate Strehlitz
Anal Chem, https://doi.org/10.1021/ac900305y
Physiologische Assays in einem DVD Player am Beispiel der Messung des Hämatokrit
J. Burger, D. Mark, G. Roth, C. Müller, R. Zengerle, F. von Stetten, Y. Park
MikroSystemTechnik; http://www.imtek.de/data/lehrstuehle/app/dokumente/conferences-pdf/conferences-2009/burger-physiologische-assays.pdf
Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration
Fiona J. Culley, Matthew Johnson, J. Henry Evans, Sunil Kumar, Rupert Crilly, Juan Casasbuenas, Günter Roth et al.
PLoS Biol; DOI 10.1371/journal.pbio.1000159
Diffusion-Driven Device for a High-Resolution Dose- Response Profiling of Combination Chemotherapy
Analytical Chemistry; DOI 10.1021/ac900415s
Mikrofluidik-Plattform zur kontinuierlichen Aufreinigung von Biomolekülen
M. Karle, J. Miwa Dr. , S. Haeberle Dr. , G. Roth Dr. , R. Zengerle Prof. Dr. , F. von Stetten Dr.
Chemie Ingenieur Technik; https://doi.org/10.1002/cite.200950483
Kontinuierlich arbeitende Mikrofluidik-Plattform zur Aufreinigung von Biomolekülen
Karle, Marc; Haeberle, Stefan; Miwa, Junichi; Roth, Günter; Zengerle, Roland; Stetten, Felix von Stetten
MikroSystemTechnik; https://www.vde-verlag.de/proceedings-de/453183028.html
Isothermal Polymerase Amplification in a Centrifugal Microfluidic Foil Cartridge
S.Lutz, P.Weber, M.Focke, B.Faltin, G.Roth, O.Piepenburg, N.Armes, D.Mark, R.Zengerle, F.von Stetten
Procedia Chemistry; DOI 10.1016/j.proche.2009.07.132
Lab-on-a-Chip Foundry Service: Schnelle kundenspezifische Implementierung miniaturisierter biochemischer Assays
Metz, T.; Karle, M.; Preis, T.; Mark, D.; Roth, G.; Müller, C. et al.
MikroSystemTechnik; https://www.vde-verlag.de/proceedings-en/453183038.html
Stimulus Dependence of the Action of Small-Molecule Inhibitors in the CD3/CD28 Signalling Network
Karsten Köhler Dr., Alexander Ganser, Thomas André Dr., Günter Roth Dr., Ludger Grosse-Hovest Dr., Gundram Jung Prof. Dr., Roland Brock Prof. Dr
ChemMedChem; DOI 10.1002/cmdc.200800134
Ubiquitin Binds to a Short Peptide Segment of Hydrolase UCH-L3: A Study by FCS, RIfS, ITC and NMR
Günter Roth Dr., Stefan Freund Dr., Bernd Möhrle Dr., Karin Wöllner, Jente Brünjes Dr. Günter Gauglitz Prof. Dr. et al.
ChemBioChem; https://doi.org/10.1002/cbic.200600254
SELEX – A (r)evolutionary method to generate high-affinity nucleic acid ligands
Regina Stoltenburg, Christine Reinemann, Beate Strehlitz
Biomol Eng, https://doi.org/10.1016/j.bioeng.2007.06.001
Development of aptamers as new receptors for environmental biosensors
Regina Stoltenburg, Christine Reinemann, Beate Strehlitz
In: Environmental Biotechnology, Ed.: Mishra C.S.K., Juwarkar A.A., APH Publishing Corporation, 2007, ISBN: 81-313-01850
Diffusion along microfluidic channels
A.Heeren, C.P.Luo, G.Roth, A.Ganser, R.Brock, K.-H.Wiesmueller et al.
Microelectronic Engineering; DOI 10.1016/j.mee.2006.01.187
Measuring biomolecular binding events with a compact disc player device
Sebastian A. Lange Dr., Günter Roth, Silke Wittemann Dr., Thilo Lacoste Dr., Andreas Vetter, Jürgen Grässle et al.
Angewandte Chemie; DOI 10.1002/ange.200501243
Microsystems for the analysis of cellular signal transduction
Alexander Ganser, Günter Roth, Karsten Köhler, Thomas André, Andreas Heeren, Wolfgang Henschel et al.
NanoBiotechnology; DOI 10.1007/s12030-005-0039-3
In vitro selection of DNA aptamers binding ethanolamine
Doerthe Mann, Christine Reinemann, Regina Stoltenburg, Beate Strehlitz
Biochem Biophys Res Chem, https://doi.org/10.1016/j.bbrc.2005.10.172
FluMag-SELEX as an advantageous method for DNA aptamer selection
Regina Stoltenburg, Christine Reinemann, Beate Strehlitz
Anal Bioanal Chem, https://doi.org/10.1007/s00216-005-3388-9